ABSTRACT

Introduction: The idea of the gut-skin axis has gained significance as a conceptual framework for understanding the interconnection between intestinal well-being, immune regulation, systemic inflammation, and various skin conditions. Psoriasis is an autoimmune-mediated dermatological condition characterized by immune system dysregulation, changes in the composition of the gut microbiome and high intestinal permeability. This perspective is explained by Ayurveda using the concepts of Agni, Ama, Dosha and Rakta Dushti. Kitibha Kushta can be understood in terms of alterations in the GI tract. Objectives: To discuss the significance of the gut-skin axis in psoriasis from a contemporary perspective and an Ayurvedic viewpoint, especially considering Agni, Ama and Kitibha Kushta. Methods: An integrative review of the topic was performed utilizing classical texts of Ayurveda like Charaka Samhita, Sushruta Samhita and Ashtanga Hridaya, along with recent scientific literature about psoriasis, gut bacteria, permeability and systemic inflammation. Results: Recent scientific research reveals that dysbiosis in the gut, intestinal barrier dysfunction, and immunologically mediated inflammatory responses play significant roles in the pathogenesis of psoriasis. The Ayurvedic literature presents similar concepts by discussing Agnimandya, which leads to the formation of Ama, Srotorodha, and the vitiation of Rasa and Rakta Dhatu. Kitibha Kushta elucidates the role of metabolic and dietary factors in the pathogenesis of dermatological conditions. Conclusions: The ancient Ayurvedic wisdom of Agni and Ama offers an elaborate explanation for understanding the gut-skin axis in psoriasis. An integrative strategy based on the principles of digestion correction and dietary regulation may be beneficial for the prevention and treatment of psoriasis. Clinical significance: Understanding the gut-skin axis underscores the importance of gut health, digestion, and systemic inflammation in the pathogenesis of psoriasis. The study of psoriasis from an Ayurvedic perspective, focusing on Agni and Ama, offers an integrated approach to its prevention and treatment. Keywords- Agni, Ama, Gut dysbiosis, Gut-Skin Axis, Kitibha Kushta, Psoriasis