ABSTRACT

Ayurveda, the Indian art of healing, focuses on maintaining health and preventing disease with care personalized to the balance of Doshas (humors), Dhatus (tissues) and Malas (waste products). One of the key concepts in Ayurvedic pathology is Shatkriyakala as explained by Acharya Sushruta in the Sushruta Samhita. Shatkriyakala are the six stages of disease development: Sanchaya (accumulation), Prakopa (aggravation), Prasara (spread), Sthanasamshraya (localization), Vyakti (manifestation), and Bheda (complication). Every stage is its own window of opportunity for intervention and treatment. This paradigm, in addition to serving as a timely diagnosis and personalized treatment approach, is preventive in nature, capable of halting disease progression prior to clinical symptomology. This review therefore critically examines classical Ayurvedic literature and modern research to assess the importance, uses and modern relevance of shatkriyakala. It underscores the significance of detecting early pathological shifts via Ayurvedic diagnostic tools and describes therapeutic approaches for each stage. We cover clinical applications in abscess (Vidradhi), allergic rhinitis (Pratishyaya) and even complex diseases like cancer, to highlight Shatkriyakala’s wide applicability in contemporary integrative medicine. The review investigates connections between Shatkriyakala and contemporary notions of homeostasis, pathogenesis, and preventive medicine. As the world turns toward personalized, predictive, and preventive medicine, Shatkriyakala presents a centuries-proven, systematic framework to decipher disease pathogenesis and interception. When combined with modern clinical models this idea maintains deep relevance in personal and public health planning. Keywords : Shatkriyakala, Sanchaya ,Prakopa, Prasara ,Sthanasamshraya