ABSTRACT
Background: The gut–brain axis is a bidirectional communication system linking gastrointestinal physiology with emotional and cognitive centers. Disturbances in this axis contribute to altered appetite regulation, emotional eating, and metabolic disorders. Ayurveda conceptualizes this relationship through Agni (digestive fire), Ama (metabolic toxins), and Manasika Bhava (psychological factors), where impaired Agni leads to Ama accumulation and Medodhatu vriddhi, ultimately manifesting as Sthoulya (overweight/obesity).
Objective: To evaluate the efficacy of Ayurvedic detox drinks in promoting weight loss by modulating the gut–brain axis and restoring Agni.
Methods: A single-case clinical study was conducted on a 38-year-old female (BMI 28.1 kg/m²) presenting with Adhmana (bloating), Alasya (lethargy), impaired concentration, restlessness, and emotional eating behavior. A 30-day intervention protocol comprising seven Ayurvedic detox drinks—Jeera water, Ajwain water, Saunf water, Methi infusion, Triphala decoction, Lemon–Honey Ushnodaka, and Jeera–Ajwain–Saunf combination water—was administered alongside dietary regulation (Laghu Ahara) and lifestyle modifications including pranayama and mindful eating.
Results: After 30 days, the patient showed a reduction of 3.8 kg body weight, improvement in digestive function, normalization of bowel habits, reduced bloating, enhanced satiety, and significant decline in emotional eating episodes. Psychological parameters such as restlessness and lack of concentration also improved, indicating better mind–gut coordination.
Conclusion: Ayurvedic detox drinks effectively restored Agni, facilitated Ama Pachana, and contributed to regulation of the gut–brain axis, resulting in sustainable weight loss and improved psychological well-being. This integrative approach highlights the relevance of Ayurveda in managing metabolic disorders through holistic gut–mind modulation.
Keywords: Gut–brain axis, Agni, Ama, Sthoulya, detox drinks, emotional eating, Ayurveda, Ushnodaka, Medodhatu, gut–mind modulation.